Moreover, a cluster of lncRNAs targeted the important genes, such as MFGE8, CD22, CD19, IL4R, LTB, and CH242-402I11.1 played important roles in IBD, Jak-STAT signaling pathway, T cell receptor signaling pathway, B cell receptor signaling pathway, MAPK signaling pathway, and NF-kappa B signaling pathway. Here, PPIB is linked to inflammatory bowel disease.