It is also noteworthy that the activation of GPR110/cAMP signaling has been shown to suppress neuroinflammation caused by traumatic brain injury [15] or endotoxin administration [28], indicating the possibility that these GPR110 ligands may be similarly effective in ameliorating inflammation-associated neuropathological conditions such as ischemia and Alzheimer’s disease. The gene discussed is ADGRF1; the disease is early-onset autosomal dominant Alzheimer disease.