Thus, the type of bone disorder evolves over time, and the disease pattern may change substantially, e.g., from a PTH-induced high turnover bone disease to suppression of PTH by high dose active vitamin D treatment and/or high calcium intakes, resulting in the histological phenotype of an adynamic bone, which confers a particularly high risk of vascular calcification since calcium binding capacity of the bone is suppressed [13]. This evidence concerns the gene PTH and bone disorder.