Compared with all recognizable lysine demethylases belonging to the JARID or KDM family in humans, KDM5D was relatively highly expressed in HNSCC tumors and cisplatin-resistant cells; this finding serves as preliminary evidence that KDM5D can be used to identify tumorigenesis and indicate the treatment resistance of HNSCC cells (Figure 1D). Here, KDM5D is linked to head and neck squamous cell carcinoma.