In the case of the older group of PBC patients, estriol (E3) was negatively correlated with IL-10 (r = −0.423, p = 0.027), IL-1β (r = −0.523, p = 0.0026), and TNF-α (r = −0.401, p = 0.027) (see Table 1). Here, TNF is linked to primary biliary cholangitis.