ABCA4 and age-related macular degeneration: In conclusion, norbixin (BIO201) efficacy in an in vitro model of RPE dysfunction and in vivo models of AMD using several strains of mice (WT and genetically modified (ABCA4−/−RDH8−/−) double knock-out mice) and WT rats have been presented in our three previous articles: [4,5,7].