Accordingly, it could be shown that CXCL10 modulates the infiltration of anti-tumorigenic immune cells in HCC while CXCL5 promotes proliferation, migration, and invasion of HCC cells through the activation of PI3K and ERK1/2 signaling pathways with consecutive infiltration of neutrophils [9,10]. This evidence concerns the gene MAPK3 and hepatocellular carcinoma.