CXCL8 and hepatocellular carcinoma: Moreover, CCL20 and CXCL8 were associated with macrovascular invasion (MVI), being significantly increased in HCC patients with MVI compared to HCC patients without MVI (CCL20 ng/mL = 74 (17–484) vs. 38 (10–450), p = 0.013; CXCL8 ng/mL = 335 (31–1395) vs. 127 (13–960), p = 0.04) (Figure 2B).