MAPT and Alzheimer disease: The progressive extracellular secretion of toxic amyloid-β (Aβ) peptide species further framed in amyloid plaques and neurofibrillary tangles (NFTs) formed by the intraneuronal aggregation of abnormally modified Tau protein isoforms, together with neuroinflammatory processes are the major neuropathological hallmarks of AD [1,2,3].