DEFB1 and squamous cell carcinoma: In general, when added to different cancer cell lines, the tested cytostatic agents significantly suppressed the expression of hBDs, except for vincristine which caused a significant upregulation of hBD-1 and hBD-4 in a breast cancer cell line (MCF7) and doxorubicin which significantly upregulated the expression of hBD-3 and hBD-4 in an epidermoid carcinoma cell line (A431) [124].