SOX2 and Alzheimer disease: Additionally, the number of Sox2+ and Brdu+-positive cells was determined compared with untreated 3xTg AD mice; treated mice exhibited significant increased numbers of Sox2+ and Brdu+ positive cells in both the 6.7 mg/mL and 20 mg/mL treatment groups (Figure 5B,C), indicating that extract promoted the survival and proliferation of NPs in 3xTg AD mice.