Indeed, Zamberletti and colleagues (2015) reported that the cognitive impairments and behavioral effects induced by adolescent Δ9-THC exposure in female rats were associated with long-term neuroinflammatory effects characterized by altered microglial morphology; increased expression of pro-inflammatory cytokines, such as TNF-α, inducible Nitric Oxide Synthase (iNOS), and Cyclooxygenase-2 (COX-2); and a reduction in the anti-inflammatory cytokine IL-10 [260]. This evidence concerns the gene PTGS2 and Cognitive impairment.