AGA and Fabry disease: Fabry disease (FD; MIM: 301500) is a lysosomal storage disorder (LSD) with an X-linked inheritance secondary to mutations in the GLA gene (NCBI: NC_000023.11; Xq22), which results in the absent or decreased activity of lysosomal hydrolase α-galactosidase A (AGA, α-GalA; BRENDA: EC3.2.1.22).