In a multivariate Cox regression analysis model, after the adjustment for relevant prognostic clinicopathological parameters in ccRCC (T-stage ≥ T2, sarcomatoid features, positive lymph node status, vascular invasion, grading > G2), an independent prognostic character of CXCR4 expression was not confirmed (Table 5). The gene discussed is CXCR4; the disease is nonpapillary renal cell carcinoma.