The findings of the present study show that LMN prevented behavioral deficits, reduced α-synuclein expression, rescued loss of dopaminergic neurons, mitigated oxidative stress, restored complex-I activity, reduced lipid peroxidation, and downregulated proinflammatory cytokines along with a favorable modulation of apoptotic pathways, including MAPK, mTOR, and Hippo signaling, in ROT-induced PD in rats. Here, MTOR is linked to Parkinson disease.