Since we previously reported an association between hepatic OLFM2 expression and NAFLD progression [19], and given that this protein, which is highly expressed in adipose tissue [18], is associated with the regulation of lipid metabolism [14,16], we believe that it is both interesting and novel to study the expression of OLFM2 in adipose tissue (SAT and VAT) and its implication in obesity-associated NAFLD [4]. The gene discussed is OLFM2; the disease is metabolic dysfunction-associated steatotic liver disease.