It should also be noted that, in addition to multiple sclerosis, modulation of S100B has been shown to be relevant in the pathogenic processes of a number of neural disorders involving astrocytes, such as the aforementioned AD, Parkinson’s disease, amyotrophic lateral sclerosis, and acute traumatic and vascular neural injury [6,8]. Here, S100B is linked to amyotrophic lateral sclerosis.