Roland’s group conducted a study using three different BC murine models (MDA-MB-231 xenograft, 4T1 syngeneic, and a transgenic model with MMTV-PyMT mice) to study the effects of different anti-VEGF therapies, including r84, on tumor vasculature, immune cell infiltration, and cytokine levels. The gene discussed is VEGFA; the disease is breast cancer.