As shown in Table 2, the in vitro cytotoxicity of 33 against these three and the wild-type (WT) pancreatic cancer cells, as well as its in vivo anticancer efficacy in the four corresponding mouse xenograft models, provided concrete evidence favoring the Cys234 residue of eEF1A1 as the binding site for 33 [130]. The gene discussed is EEF1A1; the disease is familial pancreatic carcinoma.