The mitochondrial coding and non-coding RNA are increased in the circulating extracellular vesicles in AD and mild cognitive impairment (MCI) [25,26]; the AD genes in the category of this study include MT-ND1-4,6, MT-ND4L, MT-ATP6, MT-ATP8, MT-CYB (or MT-CYBT), MT-CO1, and MT-RNR1 (Table 1). This evidence concerns the gene MT-ND4L and Alzheimer disease.