IDH2 and hepatocellular carcinoma: Isocitrate dehydrogenase 2 (IDH2) reduces HCC metastasis via matrix metallopeptidase 9 (MMP9) [33], and stearoyl-CoA-desaturase 1 (SCD1) regulates modulation of P53, Wnt/β-catenin, and autophagy in HCC [34,35,36].