The effect of flavonoids on certain inflammatory cytokines, i.e., TNF-α [222,223,224], which plays an important role in mediation of cancers, is affected by flavonoids exerting specific effects on the PI3K/Akt/mTOR signaling axis (phosphatidylinositide-3-kinases/protein kinase, mammalian target) in the cancer cells. The gene discussed is WEE1; the disease is cancer.