INS and Hyperglycemia: In the experiments on insulin release, the authors observed the slow release of insulin at the glucose concentration of (100 mg·dL−1), while, at the concentration of glucose of 250 mg·dL−1 mM, the most efficient insulin release (40%) was observed, which confirms the sensitivity of insulin-GOx-loaded vesicles were unsensitive to a normal concentration of glucose and quite sensitive to the condition of hyperglycemia.