SLC16A1 and adenocarcinoma: However, when looking at oesophagal adenocarcinomas, it was described that low MCT1 cytoplasmic expression by cancer cells associated with high tumour stage, presence of lymph node and distant metastasis, and low survival [85], which is in accordance with the above-mentioned studies on NSCLC [69], PDAC [47] and CRC [59], reflecting the specific biological contexts of those malignancies that may be dictating MCT1 role.