Colony Stimulating Factor-1 (CSF-1) has been shown to be especially important in mediating this interaction within glioma tumors and blockade of CSF-1/CSF-1R pathway has been very effective preventing metastatic progression in many different preclinical cancer models [10,12,13,14,15,16,17,18,19]. The gene discussed is CSF1R; the disease is glioma.