SMAD4 and pancreatic neoplasm: Factors like histopathological type (adenosquamous carcinoma and undifferentiated carcinoma are considered pancreatic cancer types with a poorer prognosis than PDAC), high expression of CA 19-9 (in terms of survival after surgery, CA19-9 levels above 500 IU are related to a poor prognosis) or loss of SMAD 4 (mothers against decapentaplegic homolog 4) expression (poor prognosis) are implemented into treatment guidelines [109].