The secretion of cancer cells, depending on the type of tumor, contains a set of factors that are similar to the SASP of senescent cells (IL6, IL1-ß, TGF-β, VEGF, MMPs and others), which, in turn, activate normal stromal cells (fibroblasts, macrophages, etc.), thereby enhancing positive feedback loop and favors malignancy. The gene discussed is IL6; the disease is cancer.