TENM4 and Alzheimer disease: Of note, experimental data have shown the upregulation of both SMC4 and MCM7 in mesenchymal stem cells after vitamin C treatment; the downregulation of DDIT3, SMC4, and TENM4 in replicative senescence of human fibroblasts; the upregulation of HOXB3 and TENM4 in Alzheimer’s disease; and, finally, the deregulation of DDIT3 and SMC4 in COVID-19 disease (Table 3).