Worth a mention is the downregulation of DDIT3, SMC4, and TENM4 in replicative senescence of human fibroblasts; the upregulation of SMC4 and MCM7 after vitamin C treatment; the upregulation of HOXB3 and TENM4 in Alzheimer’s disease; and the deregulation of DDIT3 and SMC4 in COVID-19 disease. The gene discussed is SMC4; the disease is early-onset autosomal dominant Alzheimer disease.