As an example, we previously demonstrated that indirubin E804, [Indirubin-3′-(2,3 dihydroxypropyl)-oximether] has anti-inflammatory properties in LN-18 and T98G glioma cells [46], which is significant because glioma cells are considered pro-inflammatory in nature by virtue of high levels of IL-6 secretion, but are also immunomodulatory via high levels of TGF-β secretion [48,49,50]. This evidence concerns the gene TGFB1 and central nervous system cancer.