Tumorigenic effects of the 8q24 gain in PC may also be caused by neighboring oncogenic sequences coding for long noncoding RNAs (lncRNAs; PCAT1, CASC19, PRNCR1, CCAT1, CASC8, CCAT2, CASC11, PVT1, TMEM75 and CCDC26, all associated with various cancers) or microRNAs (miRNAs/miR; miR-1204, miR-1205, miR-1206, miR-1207-5p, miR-1207-3p and miR-1208). The gene discussed is CASC8; the disease is pachyonychia congenita.