PCSK9 and atherosclerosis: HCAEC is the most appropriate cell line to be used in anti-atherogenic studies due to several factors: (1) PCSK9 is expressed by the endothelial cell [36]; (2) Atherosclerosis is a disease related to the arteries; and (3) HCAEC is the cell that lines the innermost layer of the coronary artery blood vessels.