The above samples share some somatic cancer related single nucleotide variants (SNVs) of driver genes, including KAT6B (NM_001256468: exon 5: c.C845T: p.A282V), TP53 (NM_001126115: exon 3: c.277_279 del: p.93_93del) and CYLD (NM_001042355: exon 9: c.A1577C: p.K526T) (Figure 1H). Here, CYLD is linked to cancer.