More recently, a duplication of two amino acids (FA531–532dup) in exon 15 of Tulp1 was determined to cause an aggressive form of IRD: Leber congenital amaurosis (LCA), or, early-onset retinal degeneration (EORD), in an Algerian family [63]. The gene discussed is TULP1; the disease is Leber congenital amaurosis.