The possible use of other biomarkers for PH diagnosis in SLE, including antiphospholipid antibody (aPL), lupus anticoagulant (LA), anti-cardiolipin (aCL), anti-U1 RNP, endothelin-1 (ET-1), and uric acid (UA) levels, has also been considered in the literature [5,25,38,39]. This evidence concerns the gene EDN1 and systemic lupus erythematosus.