Human heat shock proteins as the main group of ‘danger signals’ (tissue damage-associated molecular patterns-DAMPs) and/or microbial HSP pathogen-associated molecular patterns (PAMPs) recognized by pattern recognition receptors (PRRs) on/in antigen-presenting cells (APCs), may induce autoimmunity in a genetically different predisposed host. The gene discussed is HSP90B2P; the disease is Autoimmunity.