In addition, reduced apoptosis in tuberculosis may be due to a higher production of IL-10 than TNF-α and NO, which is controlled by low expression of the SLC11A1 (formerly NRAMP) gene encoding macrophage protein 1, which is associated with natural resistance [7,51,58,59,60,61,62,63,64,65]. The gene discussed is TNF; the disease is tuberculosis.