A significantly higher prevalence of anti-Mtb-HSP70 and anti-Mtb-HSP65 antibodies was found in stage II sarcoidosis compared to stage I. These data suggest that Mtb-HSP65 and Mtb-HSP16 may be involved in IC formation and may also be induced in the immune response to SA and TB. The gene discussed is HSPD1; the disease is sarcoidosis.