However, the role of LOX-1 and oxLDLs is not only restricted to pathologies, such as atherosclerosis or endothelial dysfunction, but has also been associated with the progression of chronic pathologies, such as obesity [18,19], type II diabetes mellitus [20,21], and various types of cancer. This evidence concerns the gene OLR1 and obesity due to melanocortin 4 receptor deficiency.