The scavenger receptor LOX-1 is one of the most important receptors for oxLDLs, and its activation induces NADPH oxidase activity and reactive oxygen species (ROS) production, which can activate p38MAPK, ERK1/2, PI3K, NF-κB, and STAT3 signaling pathways that drive the expression of proinflammatory cytokines and the atherosclerosis progression [7,8,9,10]. The gene discussed is STAT3; the disease is atherosclerosis.