While here we aimed to explore the interactions between immune response and the leptin/pAMPK signaling at the periphery, previous work suggests that leptin may protect against ALS by its direct action on motor neurons and/or its modulation on glial cells’ activity [55], or potentially by its impact on the hypothalamic secretion of different bioactive peptides [56]. Here, LEP is linked to amyotrophic lateral sclerosis.