Lately, overcoming the problem of hypoglycemia and maintaining normoglycemia during exercise in T1D seems quite attainable, not only due to recently available technological tools such as continuous/flash glucose monitoring systems, insulin pumps, and closed loop systems, but also specifically developed protocols regarding insulin dose adjustments and carbohydrate intake in order to prevent hypoglycemia [19,22]. This evidence concerns the gene INS and Hypoglycemia.