It is important to distinguish between the myositis-specified antibodies mentioned above from myositis-associated ones (anti-Ro/SSA, anti-DNAPK, anti-PM-Scl, and anti-Scl70), which characterize overlapping syndromes such as systemic sclerosis and anti-synthetase syndrome (e.g., antibodies against histidyl-transfer-RNA-synthetase (anti Jo-1)) [45]. The gene discussed is PRKDC; the disease is myositis disease.