In an epidemiological observational study, the effect of 6 weeks of supplemented Brazil nuts (6 nuts per day, 48 μg Se) and green tea extract (800 mg of epigallocatechin-3-gallate) reduced the risk of colorectal cancer by regulating genes associated with selenoproteins, WNT signalling (β-catenin), inflammation (NF-κB), and methylation (DNMT1). Here, SELENOS is linked to colorectal cancer.