Their effect can be caused by their role in the regulation of cell cycle, proliferation and apoptosis; their participation in multiple cell signaling pathways, zinc homeostasis, tumor cell microenvironment remodeling and cell adhesion and migration; their role in angiogenesis pathways, including VEGF and MMP-9, and their role in the mediation of p53 and NF-kB activity [14]. This evidence concerns the gene VEGFA and neoplasm.