The TSS-B isoform (exon 11 to exon 12) shows no difference in expression between high and low AD neuropathology from that of full-length isoforms, indicating that the 202 isoform captured by TSS-B and lacking the SH2 domain is not significantly changed with AD relative to full-length INPP5D. This evidence concerns the gene INPP5D and Alzheimer disease.