Segerstolpe and colleagues [87] performed the transcriptome analysis of the pancreatic cells obtained from healthy individuals and T2D patients and found the downregulated expression of INS and FXYD2 genes and the upregulated expression of GPD2 and LEPROTL1 in the β-cells of T2D individuals [87]. Here, FXYD2 is linked to type 2 diabetes mellitus.