The association between dilated cardiomyopathy and biallelic loss-of-function variants in the TNNI3 gene was first suspected in the year 2004 by Murphy et al. [24], who identified two affected siblings, born from distantly consanguineous parents, carrying a homozygous alanine to valine substitution in the second residue of the gene. Here, TNNI3 is linked to dilated cardiomyopathy.