Thus, according to the available data, the p.(Arg69Alafs*8) variant fulfilled the PVS1 (homozygous truncating variant in the context of an established autosomal recessive disease), PS3 (functional assays proving the variant’s deleterious impact on protein function), PM2 (allele frequency below the population threshold for a recessive variant), and PM3_supporting (in trans detection of a rare variant, adjusted for homozygous occurrence in a single proband, [29]) criteria of ACMG variant classification. The gene discussed is TAS2R6P; the disease is autosomal recessive disease.