The rs11224561 polymorphism of the PGR gene represents a C>T change in the 3′ flanking region, which was analyzed in the current study using 2425 cases and 2658 controls from the Shanghai Endometrial Cancer Study, China (SECS), Australian National Endometrial Cancer Study, Australia (ANECS), and the Leuven Endometrial Study, Belgium (LES). Here, PGR is linked to endometrial cancer.