Moreover, the loss of CEBP regulation has been shown to lead to abnormal synaptic function and cognitive disorders in mice [76], while in rats, it has been shown that CEBP activation of IGF-1 is necessary to promote neurite outgrowth and mitochondrial respiration in the brain cortex, which can protect against neurodegenerative disorders [77]. This evidence concerns the gene IGF1 and Cognitive impairment.