The genes engaged in endoplasmic reticulum protein processing and protein degradation pathways, such as RPL7A, RPL12, RPS24, RPS19, PSMB7, and PSMD8, as well as hsa-let-7d-5p, may be key figures in the pathophysiology of Xp11 translocation RCC. Here, PSMD8 is linked to renal cell carcinoma.