PCSK9 and familial hyperaldosteronism: The tier 1 genes include that for LDL receptor (LDLR), apolipoprotein B-100 (APOB), and proprotein convertase subtilisin/kexin type 9 (PCSK9), which follow the autosomal dominant mode of inheritance, and LDLR adaptor protein 1 (LDLRAP1), which follows the autosomal recessive mode of inheritance (directly implicated in FH) [5,6].