Table 5 shows the significant variants associated with HLDL in Malays. The OSBPL7 variant c.651_652del: p.217_218del was associated with 16.89 times higher odds for hypercholesterolemia (p < 0.001). The PCSK9 rs151193009 (c.C277T: p.R93C) variant was associated with low odds for hypercholesterolemia (p = 0.001). The gene discussed is PCSK9; the disease is familial hypercholesterolemia.