ANKRD55 encodes ankyrin repeat domain-containing protein 55, which mediates protein–protein interactions and may have a role in autoimmune diseases [36], whereas MAP3K1, which is also known as MEK kinase 1, is a serine/threonine kinase that belongs to the mitogen-activated protein kinases (MAP3K) family. This evidence concerns the gene MARK2 and autoimmune disease.