MAP3K1 and open-angle glaucoma: Several GWAS have identified significant genetic association in multiple genes and loci but with a varying effect on POAG outcomes [5], including the rs2472493 (chromosome 9, Position 106735669) located upstream of the ATP-binding cassette subfamily A (ABC1) member 1 (ABCA1); rs7636836 (chromosome 3, Position 173247819) in fibronectin type III domain containing 3B (FNDC3B); and rs61275591 (chromosome 5, Position 55811313) flanking the ANKRD55–MAP3K1 intergenic loci [6,7].