For patients with variants in CNGA3 and worsening of BCVA, this outcome could also be explained by cataract, so in our study, a progressive phenotype only attributable to ACHM was only seen in patients with variants in CNGB3 and PDE6C. This finding is consistent with previous findings indicating that progressive cone [11,37] and cone-rod dystrophies [47] are more frequently reported for these two genes. Here, PDE6C is linked to Cone rod dystrophy.