Severe myopia (SER ≤ −6.00 diopters) was observed with variants in all five genes but was more frequently occurring in patients with variants in PDE6H (100%, 4 of 4 patients with myopia), PDE6C (75%, 3 of 4 patients) and GNAT2 (33%, 1 of 3 patients) than in patients with variants in CNGB3 (20%, 3 of 15 patients) and CNGA3 (17%, 1 of 6 patients). The gene discussed is CNGB3; the disease is myopia.