A local risk stratification from the German Multicenter Study Group on Adult Acute Lymphoblastic Leukemia (GMALL) is available, but only a few genetic aberrations are considered: translocations t(9;22) BCR::ABL1 and t(4;11) KMT2A::AFF1 are included as adverse risk factors. The gene discussed is ABL1; the disease is acute lymphoblastic leukemia.