CRLF2 and acute lymphoblastic leukemia: As already outlined in previous studies [15,16,51], OGM also has its limitations, which affected our ALL-gene panel analysis: The CRLF2 (Cytokine Receptor Like Factor 2) gene is involved in signaling pathways of hematopoiesis; aberrations in this gene belong to the ALL subclass BCR-ABL1-like [7].